Issue 45, 2016
From the journal:

Journal of Materials Chemistry B

The design of a multifunctional dendrimer-based nanoplatform for targeted dual mode SPECT/MR imaging of tumors†

Yu Luo,‡a   Lingzhou Zhao,‡b   Xin Li,a   Jia Yang,c   Lilei Guo,b   Guixiang Zhang,c   Mingwu Shen,*a   Jinhua Zhao*b  and  Xiangyang Shi ORCID logo *ad  

* Corresponding authors

a State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, P. R. China
E-mail: xshi@dhu.edu.cn, mwshen@dhu.edu.cn

b Department of Nuclear Medicine, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200080, P. R. China
E-mail: zhaojinhua1963@126.com

c Department of Radiology, Shanghai General Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200080, P. R. China

d CQM-Centro de Química da Madeira, Universidade da Madeira, Campus da Penteada, 9000-390 Funchal, Portugal

Abstract

A multifunctional folic acid-targeted dendrimer-based nanoplatform was designed to have both Mn(II) and 99mTc loaded via chelation. The formed nanoplatform displays good stability, cytocompatibility and hemocompatibility in a given concentration range, and can be used for targeted dual-mode single-photon emission computed tomography/magnetic resonance imaging of tumors.

Graphical abstract: The design of a multifunctional dendrimer-based nanoplatform for targeted dual mode SPECT/MR imaging of tumors

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Article information

DOI
https://doi.org/10.1039/C6TB02190E
Article type
Communication
Submitted
26 Aug 2016
Accepted
22 Sep 2016
First published
29 Sep 2016

J. Mater. Chem. B, 2016,4, 7220-7225

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The design of a multifunctional dendrimer-based nanoplatform for targeted dual mode SPECT/MR imaging of tumors

Y. Luo, L. Zhao, X. Li, J. Yang, L. Guo, G. Zhang, M. Shen, J. Zhao and X. Shi, J. Mater. Chem. B, 2016, 4, 7220 DOI: 10.1039/C6TB02190E

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