Issue 31, 2017

Proton-propelled methyl-tert-butyl ether extraction for highly efficient mass spectrometric analysis of phospholipids in human plasma

Abstract

Proton-driven molecular partitioning on aqueous/organic interfaces has significantly improved the collection efficiency of bipolar phospholipids during two-phase liquid/liquid extraction, and it has enabled supra-sensitivity in tandem mass spectrometric analysis. The underlying mechanism has been proposed by the combined factors of ion-pair and charge transfer, in which phospholipids selectively penetrate the organic/aqueous interface due to their distinct pKa value and intrinsic hydrophobicity.

Graphical abstract: Proton-propelled methyl-tert-butyl ether extraction for highly efficient mass spectrometric analysis of phospholipids in human plasma

Supplementary files

Article information

Article type
Communication
Submitted
17 May 2017
Accepted
15 Jul 2017
First published
17 Jul 2017

Anal. Methods, 2017,9, 4491-4495

Proton-propelled methyl-tert-butyl ether extraction for highly efficient mass spectrometric analysis of phospholipids in human plasma

Q. Zhou, X. Ye and B. Nie, Anal. Methods, 2017, 9, 4491 DOI: 10.1039/C7AY01250K

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