Issue 2, 2017
From the journal:

Chemical Communications

Simultaneous detection of multiple targets involved in the PI3K/AKT pathway for investigating cellular migration and invasion with a multicolor fluorescent nanoprobe†

Mingming Luan,‡a   Na Li,‡a   Wei Pan,a   Limin Yang,a   Zhengze Yua  and  Bo Tang*a  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China
E-mail: tangb@sdnu.edu.cn

Abstract

We develop a multicolor fluorescent nanoprobe for assessing cellular migration and invasion by simultaneously imaging miRNA-221, PTEN mRNA and MMP-9 involved in the PI3K/AKT pathway which can regulate cellular mobility and invasiveness.

Graphical abstract: Simultaneous detection of multiple targets involved in the PI3K/AKT pathway for investigating cellular migration and invasion with a multicolor fluorescent nanoprobe

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Article information

DOI
https://doi.org/10.1039/C6CC07605J
Article type
Communication
Submitted
19 Sep 2016
Accepted
23 Nov 2016
First published
23 Nov 2016

Chem. Commun., 2017,53, 356-359

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Simultaneous detection of multiple targets involved in the PI3K/AKT pathway for investigating cellular migration and invasion with a multicolor fluorescent nanoprobe

M. Luan, N. Li, W. Pan, L. Yang, Z. Yu and B. Tang, Chem. Commun., 2017, 53, 356 DOI: 10.1039/C6CC07605J

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