Issue 15, 2017
From the journal:

Chemical Communications

First report on bio-catalytic N-formylation of amines using ethyl formate†

Rupesh E. Patre,*a   Sanjib Mal,a   Pankaj R. Nilkanth,a   Sujit K. Ghorai,a   Sudhindra H. Deshpande,a   Myriem El Qacemi,b   Tomas Smejkal,b   Sitaram Pala  and  Bhanu N. Manjunath ORCID logo *a  

* Corresponding authors

a Syngenta Biosciences Pvt. Ltd., Santa Monica Works, Corlim, Ilhas, Goa, India
E-mail: bhanu.manjunath@syngenta.com

b Syngenta Crop Protection Muenchwilen AG., Schaffhauserstrasse, CH-4332 Stein, Switzerland

Abstract

A bio-catalyzed N-formylation reaction of different amines has been developed using ethyl formate as a formylating agent. This protocol provides a facile and convenient strategy featuring mild reaction conditions, high efficacy, a broad substrate scope and recyclability of lipase. This method also works on a large scale in high yield.

Graphical abstract: First report on bio-catalytic N-formylation of amines using ethyl formate

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C6CC07679C
Article type
Communication
Submitted
21 Sep 2016
Accepted
25 Jan 2017
First published
30 Jan 2017

Chem. Commun., 2017,53, 2382-2385

Permissions

Request permissions

First report on bio-catalytic N-formylation of amines using ethyl formate

R. E. Patre, S. Mal, P. R. Nilkanth, S. K. Ghorai, S. H. Deshpande, M. El Qacemi, T. Smejkal, S. Pal and B. N. Manjunath, Chem. Commun., 2017, 53, 2382 DOI: 10.1039/C6CC07679C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements