Issue 6, 2017
From the journal:

Chemical Communications

Use of a redox probe for an electrochemical RNA–ligand binding assay in microliter droplets†

Hélène Guyon,ab   François Mavré,b   Marjorie Catala,c   Serge Turcaud,a   Franck Brachet,c   Benoît Limoges,*b   Carine Tisné*c  and  Laurent Micouin*a  

* Corresponding authors

a Laboratoire de Chimie et Biochimie pharmacologiques et toxicologiques, UMR 8601 CNRS, Université Paris Descartes, Sorbonne Paris Cité, UFR Biomédicale, 45 rue des Saints Pères, 75006 Paris, France
E-mail: laurent.micouin@parisdescartes.fr

b Laboratoire d'Electrochimie Moléculaire, UMR 7591 CNRS, Université Paris Diderot, Sorbonne Paris Cité, 15 rue Jean-Antoine de Baïf, 75205 Paris, France
E-mail: limoges@univ-paris-diderot.fr

c Laboratoire de Cristallographie et RMN biologiques, UMR 8015, CNRS, Université Paris Descartes, Sorbonne Paris Cité, Faculté de Pharmacie, 4 av. de l'Observatoire, 75006 Paris, France
E-mail: carine.tisne@ibpc.fr

Abstract

In this work, we report an affordable, sensitive, fast and user-friendly electroanalytical method for monitoring the binding between unlabeled RNA and small compounds in microliter-size droplets using a redox-probe and disposable miniaturized screen-printed electrochemical cells.

Graphical abstract: Use of a redox probe for an electrochemical RNA–ligand binding assay in microliter droplets

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Article information

DOI
https://doi.org/10.1039/C6CC07785D
Article type
Communication
Submitted
25 Sep 2016
Accepted
21 Dec 2016
First published
21 Dec 2016

Chem. Commun., 2017,53, 1140-1143

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Use of a redox probe for an electrochemical RNA–ligand binding assay in microliter droplets

H. Guyon, F. Mavré, M. Catala, S. Turcaud, F. Brachet, B. Limoges, C. Tisné and L. Micouin, Chem. Commun., 2017, 53, 1140 DOI: 10.1039/C6CC07785D

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