Issue 2, 2017

A peptide-based synthetic transcription factor selectively down-regulates the proto-oncogene CFOS in tumour cells and inhibits proliferation

Abstract

Selectively regulating genes is an important goal in Chemical Biology. We report the development of a peptide-based synthetic transcription factor which binds the targeted DNA sequence with high affinity and single base-pair discrimination capability. When delivered inside a tumor cell, it regulated targeted genes selectively and inhibited cell proliferation.

Graphical abstract: A peptide-based synthetic transcription factor selectively down-regulates the proto-oncogene CFOS in tumour cells and inhibits proliferation

Supplementary files

Article information

Article type
Communication
Submitted
07 Oct 2016
Accepted
30 Nov 2016
First published
01 Dec 2016

Chem. Commun., 2017,53, 376-379

A peptide-based synthetic transcription factor selectively down-regulates the proto-oncogene CFOS in tumour cells and inhibits proliferation

M. Chakraborty and S. Roy, Chem. Commun., 2017, 53, 376 DOI: 10.1039/C6CC08086C

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