Issue 10, 2017
From the journal:

Chemical Communications

Hydrophobicity determines the fate of self-assembled fluorescent nanoparticles in cells†

Arthur H. A. M. van Onzen,a   Lorenzo Albertazzi,ab   Albertus P. H. J. Schenning,c   Lech-Gustav Milroya  and  Luc Brunsveld ORCID logo *a  

* Corresponding authors

a Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute of Complex Molecular Systems (ICMS), Eindhoven University of Technology, P.O. Box 513, Eindhoven, The Netherlands
E-mail: l.brunsveld@tue.nl

b Nanoscopy for Nanomedicine Group, Institute for Bioengineering of Catalonia (IBEC), Barcelona, Spain

c Laboratory of Functional Organic Materials and Devices, Department of Chemical Engineering and Chemistry and Institute of Complex Molecular Systems, Eindhoven University of Technology, P.O. Box 513, Eindhoven, The Netherlands

Abstract

The fate of small molecule nanoparticles (SMNPs) composed of self-assembling intrinsically fluorescent π-conjugated oligomers was studied in cells as a function of side-chain hydrophobicity. While the hydrophobic SMNPs remained intact upon cellular uptake, the more hydrophilic SMNPs disassembled and dispersed throughout the cytosol.

Graphical abstract: Hydrophobicity determines the fate of self-assembled fluorescent nanoparticles in cells

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Article information

DOI
https://doi.org/10.1039/C6CC08793K
Article type
Communication
Submitted
02 Nov 2016
Accepted
09 Jan 2017
First published
10 Jan 2017
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2017,53, 1626-1629

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Hydrophobicity determines the fate of self-assembled fluorescent nanoparticles in cells

A. H. A. M. van Onzen, L. Albertazzi, A. P. H. J. Schenning, L. Milroy and L. Brunsveld, Chem. Commun., 2017, 53, 1626 DOI: 10.1039/C6CC08793K

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