Issue 13, 2017
From the journal:

Chemical Communications

Self-assembled lipoprotein based gold nanoparticles for detection and photothermal disaggregation of β-amyloid aggregates†

P. A. T. Martins,a   S. Alsaiari,a   K. Julfakyan,a   Z. Nie ORCID logo b  and  N. M. Khashab ORCID logo *a  

* Corresponding authors

a Smart Hybrid Materials (SHMs) Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia
E-mail: niveen.khashab@kaust.edu.sa

b Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA

Abstract

We present a reconstituted lipoprotein-based nanoparticle platform comprising a curcumin fluorescent motif and an NIR responsive gold core. This multifunctional nanosystem is successfully used for aggregation-dependent fluorescence detection and photothermal disassembly of insoluble amyloid aggregates.

Graphical abstract: Self-assembled lipoprotein based gold nanoparticles for detection and photothermal disaggregation of β-amyloid aggregates

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Article information

DOI
https://doi.org/10.1039/C6CC09085K
Article type
Communication
Submitted
14 Nov 2016
Accepted
10 Jan 2017
First published
10 Jan 2017

Chem. Commun., 2017,53, 2102-2105

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Self-assembled lipoprotein based gold nanoparticles for detection and photothermal disaggregation of β-amyloid aggregates

P. A. T. Martins, S. Alsaiari, K. Julfakyan, Z. Nie and N. M. Khashab, Chem. Commun., 2017, 53, 2102 DOI: 10.1039/C6CC09085K

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