Iodinated cyanine dyes: a new class of sensitisers for use in NIR activated photodynamic therapy (PDT)

Jordan Atchison; Sukanta Kamila; Heather Nesbitt; Kieran A. Logan; Dean M Nicholas; Colin Fowley; James Davis; Bridgeen Callan; Anthony P McHale; John F Callan

doi:10.1039/C6CC09624G

Iodinated cyanine dyes: a new class of sensitisers for use in NIR activated photodynamic therapy (PDT)†

Jordan Atchison,^a Sukanta Kamila,^a Heather Nesbitt,^a Kieran A. Logan,^a Dean M Nicholas,^a Colin Fowley,^a James Davis,^b Bridgeen Callan,^a Anthony P McHale^a and John F Callan

*^a

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* Corresponding authors

^a Biomedical Sciences Research Institute, University of Ulster, Coleraine, Northern Ireland, UK
E-mail: j.callan@ulster.ac.uk

^b Engineering Research Institute, University of Ulster, Coleraine, Northern Ireland, UK

Abstract

A new class of iodinated cyanine dyes have been prepared for use in NIR excited photodynamic therapy (PDT) and demonstrated improved efficacy in two pancreatic cell lines as well as excellent tumour control in a murine model of the disease.

Chemical Communications

Iodinated cyanine dyes: a new class of sensitisers for use in NIR activated photodynamic therapy (PDT)†

Abstract

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Iodinated cyanine dyes: a new class of sensitisers for use in NIR activated photodynamic therapy (PDT)

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