Issue 21, 2017

Cp*Rh(iii)-catalyzed C(sp3)–H alkylation of 8-methylquinolines in aqueous media

Abstract

The rhodium(III)-catalyzed cross-coupling reaction of 8-methylquinolines with a range of allylic alcohols in water is described. This approach leads to the synthesis of various γ-quinolinyl carbonyl compounds, which are synthetically useful precursors for the construction of bioactive tetrahydroquinoline and azasteroid derivatives.

Graphical abstract: Cp*Rh(iii)-catalyzed C(sp3)–H alkylation of 8-methylquinolines in aqueous media

Supplementary files

Article information

Article type
Communication
Submitted
10 Dec 2016
Accepted
30 Jan 2017
First published
30 Jan 2017

Chem. Commun., 2017,53, 3006-3009

Cp*Rh(III)-catalyzed C(sp3)–H alkylation of 8-methylquinolines in aqueous media

S. Kim, S. Han, J. Park, S. Sharma, N. K. Mishra, H. Oh, J. H. Kwak and I. S. Kim, Chem. Commun., 2017, 53, 3006 DOI: 10.1039/C6CC09830D

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