Issue 33, 2017

The fusogenic peptide HA2 impairs selectivity of CXCR4-targeted protein nanoparticles

Abstract

We demonstrate here that the genetic incorporation of the fusogenic peptide HA2 into a CXCR4-targeted protein nanoparticle dramatically reduces the specificity of the interaction between nanoparticles and cell receptors, a factor to be considered when designing tumor-homing drug vehicles displaying endosomal-escape agents. The loss of specificity is concomitant with enhanced cell penetrability.

Graphical abstract: The fusogenic peptide HA2 impairs selectivity of CXCR4-targeted protein nanoparticles

Supplementary files

Article information

Article type
Communication
Submitted
13 Dec 2016
Accepted
10 Mar 2017
First published
10 Mar 2017
This article is Open Access
Creative Commons BY license

Chem. Commun., 2017,53, 4565-4568

The fusogenic peptide HA2 impairs selectivity of CXCR4-targeted protein nanoparticles

L. Sánchez-García, N. Serna, M. Mattanovich, P. Cazzanelli, A. Sánchez-Chardi, O. Conchillo-Solé, F. Cortés, X. Daura, U. Unzueta, R. Mangues, A. Villaverde and E. Vázquez, Chem. Commun., 2017, 53, 4565 DOI: 10.1039/C6CC09900A

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