Luciferase–Rose Bengal conjugates for singlet oxygen generation by bioluminescence resonance energy transfer

Seonghoon Kim; HyeongChan Jo; Mijeong Jeon; Myung-Gyu Choi; Sei Kwang Hahn; Seok-Hyun Yun

doi:10.1039/C7CC00041C

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Luciferase–Rose Bengal conjugates for singlet oxygen generation by bioluminescence resonance energy transfer†

Seonghoon Kim,

^ab HyeongChan Jo,^b Mijeong Jeon,

^b Myung-Gyu Choi,

^c Sei Kwang Hahn

^d and Seok-Hyun Yun

*^ab

Author affiliations

* Corresponding authors

^a Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, USA
E-mail: syun@hms.harvard.edu

^b Graduate School of Nanoscience and Technology, Korea Advanced Institute of Science and Technology, Korea

^c Division of Gastroenterology, Dept. of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, Catholic University, Korea

^d Department of Materials Science and Engineering, Pohang University of Science and Technology, Korea

Abstract

Conjugates of Rose Bengal and Renilla luciferase generated singlet oxygen upon binding with coelenterazine via bioluminescence resonance energy transfer (BRET). Since the applications of conventional PDT have been limited to superficial lesions due to the limited light penetration in tissue, BRET activated PDT which does not require external light illumination may overcome the limitations of conventional PDT.

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Supplementary information PDF (303K)

Article information

DOI: https://doi.org/10.1039/C7CC00041C
Article type: Communication
Submitted: 03 Jan 2017
Accepted: 28 Mar 2017
First published: 28 Mar 2017
This article is Open Access

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Chem. Commun., 2017,53, 4569-4572

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Luciferase–Rose Bengal conjugates for singlet oxygen generation by bioluminescence resonance energy transfer

S. Kim, H. Jo, M. Jeon, M. Choi, S. K. Hahn and S. Yun, Chem. Commun., 2017, 53, 4569 DOI: 10.1039/C7CC00041C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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Chemical Communications

Luciferase–Rose Bengal conjugates for singlet oxygen generation by bioluminescence resonance energy transfer†

Abstract

Supplementary files

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Luciferase–Rose Bengal conjugates for singlet oxygen generation by bioluminescence resonance energy transfer

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