Issue 21, 2017
From the journal:

Chemical Communications

A mitochondria-targeting supramolecular photosensitizer based on pillar[5]arene for photodynamic therapy†

Leilei Rui,a   Yudong Xue,a   Yong Wang,b   Yun Gaoa  and  Weian Zhang*a  

* Corresponding authors

a Shanghai Key Laboratory of Advanced Polymeric Materials, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China
E-mail: wazhang@ecust.edu.cn
Fax: +86 21 64253033
Tel: +86 21 64253033

b State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemistry and Chemical Engineering, Nanjing Tech University, Nanjing 210009, China

Abstract

A mitochondria-targeting supramolecular photosensitizer system TPP-QAS/WP5/DTAB was constructed based on a host–guest inclusion complex. The supramolecular system could efficiently release and activate TPP-QASs in an acidic environment, which have been demonstrated to preferentially accumulate in mitochondria. Singlet oxygen (1O2) could be in situ generated in mitochondria under light irradiation, further enhancing the PDT efficacy.

Graphical abstract: A mitochondria-targeting supramolecular photosensitizer based on pillar[5]arene for photodynamic therapy

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Article information

DOI
https://doi.org/10.1039/C7CC00950J
Article type
Communication
Submitted
06 Feb 2017
Accepted
14 Feb 2017
First published
16 Feb 2017

Chem. Commun., 2017,53, 3126-3129

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A mitochondria-targeting supramolecular photosensitizer based on pillar[5]arene for photodynamic therapy

L. Rui, Y. Xue, Y. Wang, Y. Gao and W. Zhang, Chem. Commun., 2017, 53, 3126 DOI: 10.1039/C7CC00950J

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