Issue 40, 2017
From the journal:

Chemical Communications

Self-assembled DNA nanocentipedes as multivalent vehicles for enhanced delivery of CpG oligonucleotides†

Wenshan Li,a   Lei Luo,a   Jin Huang,a   Qing Wang, ORCID logo a   Jianbo Liu,a   Xiao Xiao,a   Hongmei Fang,a   Xiaohai Yang ORCID logo *a  and  Kemin Wang ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha 410082, China
E-mail: yangxiaohai@hnu.edu.cn, kmwang@hnu.edu.cn

Abstract

We report self-assembled nanocentipedes as multivalent vehicles for the delivery of immunostimulatory CpG ODNs. The multivalent vehicles could be internalized by RAW264.7 cells and stimulate the secretion of large amounts of cytokines, successively inducing effective apoptosis of cancer cells.

Graphical abstract: Self-assembled DNA nanocentipedes as multivalent vehicles for enhanced delivery of CpG oligonucleotides

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Article information

DOI
https://doi.org/10.1039/C7CC01128H
Article type
Communication
Submitted
13 Feb 2017
Accepted
18 Apr 2017
First published
18 Apr 2017

Chem. Commun., 2017,53, 5565-5568

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Self-assembled DNA nanocentipedes as multivalent vehicles for enhanced delivery of CpG oligonucleotides

W. Li, L. Luo, J. Huang, Q. Wang, J. Liu, X. Xiao, H. Fang, X. Yang and K. Wang, Chem. Commun., 2017, 53, 5565 DOI: 10.1039/C7CC01128H

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