Issue 36, 2017

Conjunctive functionalization of vinyl boronate complexes with electrophiles: a diastereoselective three-component coupling

Abstract

A method for the conjunctive functionalization of vinyl boronate complexes with electrophiles is described. The overall process represents a three-component coupling between a vinyl boronic ester, carbon nucleophile and an electrophile, thus affording complex multifunctionalized products from simple starting materials. The diastereoselectivity (syn or anti) of this process is strongly dependent upon the nature of the electrophile.

Graphical abstract: Conjunctive functionalization of vinyl boronate complexes with electrophiles: a diastereoselective three-component coupling

Supplementary files

Article information

Article type
Communication
Submitted
03 Mar 2017
Accepted
07 Apr 2017
First published
20 Apr 2017
This article is Open Access
Creative Commons BY license

Chem. Commun., 2017,53, 4922-4925

Conjunctive functionalization of vinyl boronate complexes with electrophiles: a diastereoselective three-component coupling

R. J. Armstrong, C. Sandford, C. García-Ruiz and V. K. Aggarwal, Chem. Commun., 2017, 53, 4922 DOI: 10.1039/C7CC01671A

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