Issue 43, 2017
From the journal:

Chemical Communications

An eco-friendly in situ activatable antibiotic via cucurbit[8]uril-mediated supramolecular crosslinking of branched polyethylenimine†

Shengke Li,‡a   Nan Jiang,‡b   Wenxuan Zhao,a   Yuan-Fu Ding,ac   Ying Zheng,a   Lian-Hui Wang, ORCID logo c   Jun Zheng*b  and  Ruibing Wang ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macau SAR, China
E-mail: rwang@umac.mo

b Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau SAR, China
E-mail: junzheng@umac.mo

c Key Laboratory for Organic Electronics and Information Displays, Institute of Advanced Materials, Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210046, China

Abstract

We report an unprecedented, eco-friendly, in situ activatable model antibiotic, phenylalanyl-polyethylenimine (PhePEI), to potentially diminish antibiotic pollution of the environment and associated antibiotic resistance. The inactive PhePEI can be reversibly activated upon supramolecular crosslinking by cucurbit[8]uril, conferring potent antibacterial activity.

Graphical abstract: An eco-friendly in situ activatable antibiotic via cucurbit[8]uril-mediated supramolecular crosslinking of branched polyethylenimine

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Article information

DOI
https://doi.org/10.1039/C7CC02466E
Article type
Communication
Submitted
30 Mar 2017
Accepted
08 May 2017
First published
08 May 2017

Chem. Commun., 2017,53, 5870-5873

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An eco-friendly in situ activatable antibiotic via cucurbit[8]uril-mediated supramolecular crosslinking of branched polyethylenimine

S. Li, N. Jiang, W. Zhao, Y. Ding, Y. Zheng, L. Wang, J. Zheng and R. Wang, Chem. Commun., 2017, 53, 5870 DOI: 10.1039/C7CC02466E

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