Facile solvent-free fabrication of nitric oxide (NO)-releasing coatings for prevention of biofilm formation

Abstract

We describe a simple and solvent-free method to generate nitric oxide (NO)-releasing coatings by incorporating diazeniumdiolate (NONOate) into allylamine or diallylamine plasma polymer coatings. The resulting coatings demonstrate continuous release of NO for over 48 hours and are effective at reducing the adhesion and biofilm formation of medically-relevant Gram-negative and Gram-positive opportunistic pathogens.