Issue 48, 2017
From the journal:

Chemical Communications

Gold-catalyzed diastereoselective domino dearomatization/ipso-cyclization/aza-Michael sequence: a facile access to diverse fused azaspiro tetracyclic scaffolds†

Yi He,a   Zhenghua Li, ORCID logo ‡*a   Guilong Tian,a   Liangliang Song,a   Luc Van Meervelt ORCID logo b  and  Erik V. Van der Eycken ORCID logo *ac  

* Corresponding authors

a Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, KU Leuven, Celestijnenlaan 200F, Belgium
E-mail: ahlzhchem@gmail.com, erik.vandereycken@kuleuven.be

b Biomolecular Architecture, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, Leuven, Belgium

c Peoples Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya street, Moscow, Russia

Abstract

A facile and diversity-oriented access to complex tetracyclic benzo[e]pyrrolo[2,3-c]indole-2,4,7(5H)-triones through a post-Ugi gold(I)-catalyzed domino dearomatization/ipso-cyclization/aza-Michael sequence is elaborated. This process furnishes tetracyclic scaffolds in good yields from readily available precursors with unique diastereoselectivity.

Graphical abstract: Gold-catalyzed diastereoselective domino dearomatization/ipso-cyclization/aza-Michael sequence: a facile access to diverse fused azaspiro tetracyclic scaffolds

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Article information

DOI
https://doi.org/10.1039/C7CC03152A
Article type
Communication
Submitted
24 Apr 2017
Accepted
17 May 2017
First published
23 May 2017

Chem. Commun., 2017,53, 6413-6416

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Gold-catalyzed diastereoselective domino dearomatization/ipso-cyclization/aza-Michael sequence: a facile access to diverse fused azaspiro tetracyclic scaffolds

Y. He, Z. Li, G. Tian, L. Song, L. Van Meervelt and E. V. Van der Eycken, Chem. Commun., 2017, 53, 6413 DOI: 10.1039/C7CC03152A

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