Issue 48, 2017
From the journal:

Chemical Communications

Photo-clickable microRNA for in situ fluorescence labeling and imaging of microRNA in living cells†

Lei Huang,a   Yingjie Chen, ORCID logo a   Lei Chen,a   Xiao Xiao,a   Xingxing Wang,a   Jinbo Li ORCID logo *a  and  Yan Zhang ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Analytical Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China
E-mail: njuzy@nju.edu.cn, jinboli@nju.edu.cn

Abstract

A photo-clickable microRNA whose fluorescence was able to be turned on by mild light irradiation was constructed and the in situ fluorescence turn-on of the photo-clickable microRNA-122 in living cells was demonstrated by light irradiation with spatial and temporal resolution.

Graphical abstract: Photo-clickable microRNA for in situ fluorescence labeling and imaging of microRNA in living cells

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Article information

DOI
https://doi.org/10.1039/C7CC03328A
Article type
Communication
Submitted
29 Apr 2017
Accepted
24 May 2017
First published
24 May 2017

Chem. Commun., 2017,53, 6452-6455

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Photo-clickable microRNA for in situ fluorescence labeling and imaging of microRNA in living cells

L. Huang, Y. Chen, L. Chen, X. Xiao, X. Wang, J. Li and Y. Zhang, Chem. Commun., 2017, 53, 6452 DOI: 10.1039/C7CC03328A

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