Issue 68, 2017

Nonconventional difluoroalkylation of C(sp2)–H bonds through hydroarylation

Abstract

An unprecedented Rh-catalyzed C2-difluoroalkylation of indole derivatives with 2,2-difluorovinyl arenesulfonates has been reported. This reaction provides a rare instance of catalytic difluoroalkylation through hydroarylation of gem-difluoroalkenes. The sulfonate group works as a chelating ligand, thus stabilizing the rhodacycle intermediate, leading to the uncommon transformation.

Graphical abstract: Nonconventional difluoroalkylation of C(sp2)–H bonds through hydroarylation

Supplementary files

Article information

Article type
Communication
Submitted
22 Jun 2017
Accepted
31 Jul 2017
First published
01 Aug 2017

Chem. Commun., 2017,53, 9482-9485

Nonconventional difluoroalkylation of C(sp2)–H bonds through hydroarylation

C. Zhu, S. Song, L. Zhou, D. Wang, C. Feng and T. Loh, Chem. Commun., 2017, 53, 9482 DOI: 10.1039/C7CC04842D

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