Issue 95, 2017
From the journal:

Chemical Communications

Controllable engineering of asymmetric phosphatidylserine-containing lipid vesicles using calcium cations†

Hai-Yuan Sun,‡a   Geng Deng, ORCID logo ‡a   Yao-Wen Jiang,b   Yu Zhou,ac   Jing Xu,a   Fu-Gen Wu ORCID logo *b  and  Zhi-Wu Yu ORCID logo *a  

* Corresponding authors

a MOE Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China
E-mail: yuzhw@tsinghua.edu.cn

b State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, P. R. China
E-mail: wufg@seu.edu.cn

c School of Chemistry and Chemical Engineering, Qingdao University, Qingdao 266071, P. R. China

Abstract

A novel method to produce controllable asymmetric lipid vesicles using Ca2+ is reported. The enrichment of negatively charged phosphatidylserine (PS) molecules in the inner leaflet is found not due to charge–charge attraction, but rather a modulation effect on the occupying size of the headgroups of PS molecules.

Graphical abstract: Controllable engineering of asymmetric phosphatidylserine-containing lipid vesicles using calcium cations

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Article information

DOI
https://doi.org/10.1039/C7CC05114J
Article type
Communication
Submitted
02 Jul 2017
Accepted
03 Nov 2017
First published
06 Nov 2017

Chem. Commun., 2017,53, 12762-12765

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Controllable engineering of asymmetric phosphatidylserine-containing lipid vesicles using calcium cations

H. Sun, G. Deng, Y. Jiang, Y. Zhou, J. Xu, F. Wu and Z. Yu, Chem. Commun., 2017, 53, 12762 DOI: 10.1039/C7CC05114J

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