A naked-eye colorimetric sensor for Hg2+ monitoring with cascade signal amplification based on target-induced conjunction of split DNAzyme fragments

Junhua Chen; Jiafeng Pan; Shu Chen

doi:10.1039/C7CC05445A

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A naked-eye colorimetric sensor for Hg²⁺ monitoring with cascade signal amplification based on target-induced conjunction of split DNAzyme fragments†

Junhua Chen,

*^a Jiafeng Pan^a and Shu Chen^a

Author affiliations

* Corresponding authors

^a Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control and Management, Guangdong Institute of Eco-environmental Science & Technology, Guangzhou 510650, China
E-mail: 222chenjunhua@163.com

Abstract

A colorimetric sensor for the visual detection of Hg²⁺ with cascade signal amplification has been successfully constructed using split DNAzyme subunits as sensing elements and gold nanoparticles as signal reporters. The biosensor is ultrasensitive, enabling the visual detection of trace levels of Hg²⁺ as low as 10 pM without instrumentation.

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Article information

DOI: https://doi.org/10.1039/C7CC05445A
Article type: Communication
Submitted: 14 Jul 2017
Accepted: 24 Aug 2017
First published: 24 Aug 2017

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Chem. Commun., 2017,53, 10224-10227

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A naked-eye colorimetric sensor for Hg²⁺ monitoring with cascade signal amplification based on target-induced conjunction of split DNAzyme fragments

J. Chen, J. Pan and S. Chen, Chem. Commun., 2017, 53, 10224 DOI: 10.1039/C7CC05445A

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Chemical Communications