Issue 88, 2017

Nickel-catalyzed acetamidation and lactamization of arylboronic acids

Abstract

A nickel-catalyzed acetamidation and lactamization of arylboronic acids via a one-pot reaction with ynamides and N-hydroxyphthalimide is described. This protocol features with mild reaction conditions and a broad substrate scope, and has been successfully applied to late-stage functionalization of pharmaceuticals. Moreover, control reactions were conducted to elucidate a plausible mechanism.

Graphical abstract: Nickel-catalyzed acetamidation and lactamization of arylboronic acids

Supplementary files

Article information

Article type
Communication
Submitted
08 Sep 2017
Accepted
10 Oct 2017
First published
10 Oct 2017

Chem. Commun., 2017,53, 11996-11999

Nickel-catalyzed acetamidation and lactamization of arylboronic acids

B. Huang, L. Zeng, Y. Shen and S. Cui, Chem. Commun., 2017, 53, 11996 DOI: 10.1039/C7CC07055A

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