Centrifugal micropipette-tip with pressure signal readout for portable quantitative detection of myoglobin

Yanling Song; Yuan An; Weizhi Liu; Wanfu Hou; Xingrui Li; Bingqian Lin; Zhi Zhu; Shengxiang Ge; Huang-hao Yang; Chaoyong Yang

doi:10.1039/C7CC07231G

Centrifugal micropipette-tip with pressure signal readout for portable quantitative detection of myoglobin†

Yanling Song,^ab Yuan An,^b Weizhi Liu,^b Wanfu Hou,^b Xingrui Li,^b Bingqian Lin,^b Zhi Zhu,^b Shengxiang Ge,*^b Huang-hao Yang*^a and Chaoyong Yang

*^b

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* Corresponding authors

^a MOE Key Laboratory for Analytical Science of Food Safety and Biology, State Key Laboratory of Photocatalysis on Energy and Environment, College of Biological Science and Engineering, Fuzhou University, Fuzhou 350002, China
E-mail: hhyang@fzu.edu.cn

^b MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, Collaborative Innovation Center of Chemistry for Energy Materials, Key Laboratory for Chemical Biology of Fujian Province, State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, National Institute of Diagnostics and Vaccine Development in Infectious Disease Xiamen University, Xiamen 361005, China
E-mail: cyyang@xmu.edu.cn, sxge@xmu.edu.cn

Abstract

This paper describes a centrifugal micropipette-tip method for ELISA sample processing combined with a pressure meter for portable quantitative detection of acute myocardial infarction (AMI) biomarker myoglobin (Myo). The method enables sensitive and reliable quantification of Myo in 35 minutes. With the advantages of simplicity, speed, user friendliness, low cost, and small sample consumption, centrifugal micropipette-tip ELISA shows great potential for quantitative POC diagnostics for AMI.

Chemical Communications

Centrifugal micropipette-tip with pressure signal readout for portable quantitative detection of myoglobin†

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Centrifugal micropipette-tip with pressure signal readout for portable quantitative detection of myoglobin

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