A versatile palladium-catalyzed double carbonylation of aryl bromides has been developed. Using Pd(OAc)2/BuPAd2 as the catalyst system and DBU as the base, under relatively low CO pressure, various α-ketoamides were produced in good yields. In order to get insight into the reaction pathway, real time NMR studies were performed as well and a correlated reaction mechanism is been given.
C. Shen, C. Fink, G. Laurenczy, P. J. Dyson and X. Wu, Chem. Commun., 2017, 53, 12422 DOI: 10.1039/C7CC07412C
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