Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite

Adam C. Sedgwick; Hai-Hao Han; Jordan E. Gardiner; Steven D. Bull; Xiao-Peng He; Tony D. James

doi:10.1039/C7CC07845E

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Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite†

Adam C. Sedgwick,

*^a Hai-Hao Han,^b Jordan E. Gardiner,

^a Steven D. Bull,

*^a Xiao-Peng He

*^b and Tony D. James

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, University of Bath, Bath, UK
E-mail: t.d.james@bath.ac.uk, s.d.bull@bath.ac.uk

^b Key Laboratory for Advanced Materials & Feringa Nobel Prize Scientist Joint Research Center, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237, P. R. China
E-mail: xphe@ecust.edu.cn

Abstract

Two boronate fluorescent probes have been developed for the detection of peroxynitrite (TCFB1 and TCFB2). TCFB1 was shown to have a low sensitvity towards peroxynitrite and have a poor solubility in aqueous solution whereas TCFB2 demonstrated high sensitivity towards peroxynitrite and mitochondria localisation with the ability to detect exogenous and endogenous peroxynitrite in live cells (Hep-G2, RAW 264.7, HeLa and A459).

This article is part of the themed collection: Chemosensors and Molecular Logic

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Article information

DOI: https://doi.org/10.1039/C7CC07845E
Article type: Communication
Submitted: 10 Oct 2017
Accepted: 03 Nov 2017
First published: 08 Nov 2017
This article is Open Access

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Chem. Commun., 2017,53, 12822-12825

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Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite

A. C. Sedgwick, H. Han, J. E. Gardiner, S. D. Bull, X. He and T. D. James, Chem. Commun., 2017, 53, 12822 DOI: 10.1039/C7CC07845E

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Chemical Communications

Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite†

Abstract

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Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite

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