Issue 9, 2017
From the journal:

Organic & Biomolecular Chemistry

Formation of β-(1,3-1,6)-d-glucan-complexed [70]fullerene and its photodynamic activity towards macrophages†

Atsushi Ikeda, ORCID logo *a   Motofusa Akiyama,b   Kouta Sugikawa,a   Kazuya Koumoto,c   Yuta Kashijima,d   Jiawei Li,d   Toshio Suzukid  and  Takeshi Nagasaki*d  

* Corresponding authors

a Department of Applied Chemistry, Graduate School of Engineering, Hiroshima University, Higashi-Hiroshima 739-8527, Japan
E-mail: aikeda@hiroshima-u.ac.jp
Fax: +81-82-424-7734
Tel: +81-82-424-7734

b Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 113-8551, Japan

c Department of Nanobiochemistry, Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, 7-1-20 Minatojima-Minamimachi, Kobe 650-0047, Japan

d Department of Applied Chemistry and Bioengineering, Graduate School of Engineering, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan

Abstract

[70]Fullerene was dissolved in water by complexation with β-1,3-glucan using a mechanochemical high-speed vibration milling apparatus. The photodynamic activity of β-1,3-glucan-complexed C70 was highly dependent on the expression level of dectin-1 on the cell surfaces of macrophages. The photodynamic activity increased as a result of a synergistic effect between β-1,3-glucan-complexed 1′-acetoxychavicol acetate and the C70 complex.

Graphical abstract: Formation of β-(1,3-1,6)-d-glucan-complexed [70]fullerene and its photodynamic activity towards macrophages

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Article information

DOI
https://doi.org/10.1039/C6OB02747D
Article type
Paper
Submitted
16 Dec 2016
Accepted
02 Feb 2017
First published
03 Feb 2017

Org. Biomol. Chem., 2017,15, 1990-1997

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Formation of β-(1,3-1,6)-D-glucan-complexed [70]fullerene and its photodynamic activity towards macrophages

A. Ikeda, M. Akiyama, K. Sugikawa, K. Koumoto, Y. Kashijima, J. Li, T. Suzuki and T. Nagasaki, Org. Biomol. Chem., 2017, 15, 1990 DOI: 10.1039/C6OB02747D

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