A formal intermolecular [4 + 2] cycloaddition reaction of 1,3-disubstituted indoles and alkylquinones

Chao Lin; Hong-Jin Du; Hui Zhao; Ding-Fei Yan; Nai-Xin Liu; Hongbin Sun; Xiaoan Wen; Qing-Long Xu

doi:10.1039/C7OB00392G

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A formal intermolecular [4 + 2] cycloaddition reaction of 1,3-disubstituted indoles and alkylquinones†

Chao Lin,^a Hong-Jin Du,^a Hui Zhao,^a Ding-Fei Yan,^a Nai-Xin Liu,^a Hongbin Sun,^a Xiaoan Wen*^a and Qing-Long Xu

*^a

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* Corresponding authors

^a Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease and State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, China
E-mail: wxagj@126.com, qlxu@cpu.edu.cn

Abstract

A formal [4 + 2] cycloaddition reaction of 1,3-disubstituted indoles and alkylquinones was realized to furnish polycyclic indolines in good yields. This protocol proceeded smoothly under basic conditions, with high atom-economy and broad substrate scope.

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Article information

DOI: https://doi.org/10.1039/C7OB00392G
Article type: Paper
Submitted: 17 Feb 2017
Accepted: 28 Mar 2017
First published: 28 Mar 2017

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Org. Biomol. Chem., 2017,15, 3472-3478

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A formal intermolecular [4 + 2] cycloaddition reaction of 1,3-disubstituted indoles and alkylquinones

C. Lin, H. Du, H. Zhao, D. Yan, N. Liu, H. Sun, X. Wen and Q. Xu, Org. Biomol. Chem., 2017, 15, 3472 DOI: 10.1039/C7OB00392G

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Organic & Biomolecular Chemistry

A formal intermolecular [4 + 2] cycloaddition reaction of 1,3-disubstituted indoles and alkylquinones†

Abstract

Supplementary files

Article information

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A formal intermolecular [4 + 2] cycloaddition reaction of 1,3-disubstituted indoles and alkylquinones

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