Issue 17, 2017

Copper(i)-catalyzed ring-opening cyanation of cyclopropanols

Abstract

A copper(I)-catalyzed ring-opening cyanation of cyclopropanols was developed. The reaction provides an alternative method to achieve β-cyano ketones efficiently. This reaction exhibits good functional group compatibility under mild conditions and can be scaled up to the gram scale. Preliminary mechanistic studies suggest that the reaction might go through a free radical process.

Graphical abstract: Copper(i)-catalyzed ring-opening cyanation of cyclopropanols

Supplementary files

Article information

Article type
Communication
Submitted
14 Mar 2017
Accepted
06 Apr 2017
First published
06 Apr 2017

Org. Biomol. Chem., 2017,15, 3590-3593

Copper(I)-catalyzed ring-opening cyanation of cyclopropanols

Y. Feng, Y. Shu, P. Cao, T. Xu and H. Xu, Org. Biomol. Chem., 2017, 15, 3590 DOI: 10.1039/C7OB00627F

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