Issue 32, 2017
From the journal:

Organic & Biomolecular Chemistry

Calcium carbide catalytically activated with tetra-n-butyl ammonium fluoride for Sonogashira cross coupling reactions†

Abolfazl Hosseini,a   Afsaneh Pilevar,a   Eimear Hogan,a   Boris Mogwitz,b   Anne S. Schulzec  and  Peter R. Schreiner ORCID logo *a  

* Corresponding authors

a Institute of Organic Chemistry, Justus-Liebig University, Heinrich-Buff-Ring 17, 35392 Giessen, Germany
E-mail: prs@uni-giessen.de

b Institute of Physical Chemistry, Justus-Liebig University, Heinrich-Buff-Ring 17, 35392 Giessen, Germany

c Institute of Inorganic and Analytical Chemistry, Justus-Liebig University, Heinrich-Buff-Ring 17, 35392 Giessen, Germany

Abstract

We report a novel method for the direct synthesis of mono- and bis-arylated alkynes utilizing catalytically activated CaC2 as the alkyne component. This fluoride-activated cross coupling reaction provides advantages over existing methods regarding operational simplicity, use of readily available starting materials, and low cost.

Graphical abstract: Calcium carbide catalytically activated with tetra-n-butyl ammonium fluoride for Sonogashira cross coupling reactions

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Article information

DOI
https://doi.org/10.1039/C7OB01334E
Article type
Paper
Submitted
31 May 2017
Accepted
25 Jul 2017
First published
25 Jul 2017

Org. Biomol. Chem., 2017,15, 6800-6807

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Calcium carbide catalytically activated with tetra-n-butyl ammonium fluoride for Sonogashira cross coupling reactions

A. Hosseini, A. Pilevar, E. Hogan, B. Mogwitz, A. S. Schulze and P. R. Schreiner, Org. Biomol. Chem., 2017, 15, 6800 DOI: 10.1039/C7OB01334E

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