An indicator displacement assay has been adapted to detect the diol products of the aldol reaction between 4-nitrobenzaldehyde and hydroxyacetone in crude reaction mixtures. This provides a rapid colorimetric method of detecting product formation and thus evaluating potential catalysts, which is demonstrated using multiple catalytic peptides.
A. M. M. Gest, E. M. Aguiluz, M. T. Mays, X. Liu, E. K. Neidhart and L. S. Witus, Org. Biomol. Chem., 2017, 15, 10160 DOI: 10.1039/C7OB02032E
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