Issue 46, 2017

1,3-Dibromo-5,5-dimethylhydantoin mediated oxidative amidation of terminal alkenes in water

Abstract

A variety of terminal alkenes were converted to the corresponding amides in yields of 25 to 86% in water via treatment with 1,3-dibromo-5,5-dimethylhydantoin, followed by reaction with molecular iodine and aq. NH3 (or amine) in one pot. This metal- and organic solvent-free protocol is not only suitable for styrene derivatives, but also, for the first time, works well on terminal aliphatic alkenes.

Graphical abstract: 1,3-Dibromo-5,5-dimethylhydantoin mediated oxidative amidation of terminal alkenes in water

Supplementary files

Article information

Article type
Paper
Submitted
18 Sep 2017
Accepted
08 Nov 2017
First published
09 Nov 2017

Org. Biomol. Chem., 2017,15, 9889-9894

1,3-Dibromo-5,5-dimethylhydantoin mediated oxidative amidation of terminal alkenes in water

C. Ma, G. Fan, P. Wu, Z. Li, Y. Zhou, Q. Ding and W. Zhang, Org. Biomol. Chem., 2017, 15, 9889 DOI: 10.1039/C7OB02329D

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