An effective route to β2-amino acid derivatives via Pd-catalyzed regioselective hydrocarboxylation of 1,2-disubstituted enimides

Jie Dai; Wenlong Ren; Wenju Chang; Ping Zhang; Yian Shi

doi:10.1039/C6QO00353B

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An effective route to β²-amino acid derivatives via Pd-catalyzed regioselective hydrocarboxylation of 1,2-disubstituted enimides†

Jie Dai,^a Wenlong Ren,^a Wenju Chang,^a Ping Zhang^a and Yian Shi*^ab

Author affiliations

* Corresponding authors

^a State Key Laboratory of Coordination Chemistry, Collaborative Innovation Center of Chemistry for Life Sciences, Center for Multimolecular Organic Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China

^b Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA
E-mail: Yian.Shi@colostate.edu

Abstract

An effective Pd(0)-catalyzed hydrocarboxylation of 1,2-disubstituted enimides with formic acid and HCOOPh is described. A variety of β²-amino acid derivatives are obtained in good yield with high regioselectivity without using external toxic CO gas.

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Article information

DOI: https://doi.org/10.1039/C6QO00353B
Article type: Research Article
Submitted: 17 Aug 2016
Accepted: 19 Oct 2016
First published: 03 Nov 2016

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Org. Chem. Front., 2017,4, 297-302

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An effective route to β²-amino acid derivatives via Pd-catalyzed regioselective hydrocarboxylation of 1,2-disubstituted enimides

J. Dai, W. Ren, W. Chang, P. Zhang and Y. Shi, Org. Chem. Front., 2017, 4, 297 DOI: 10.1039/C6QO00353B

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