Issue 3, 2017
From the journal:

Organic Chemistry Frontiers

Acid-promoted denitrogenative Pd-catalyzed addition of arylhydrazines with nitriles at room temperature†

Kai Cheng,a   Guofang Wang,a   Mengting Menga  and  Chenze Qi*a  

* Corresponding authors

a Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Shaoxing University, Shaoxing, People's Republic of China
E-mail: qichenze@usx.edu.cn
Fax: +86-575-88345683
Tel: +86-575-88345683

Abstract

The Pd(TFA)2-catalyzed denitrogenative addition proceeded with selective C–N bond cleavage of arylhydrazines with nitriles in the presence of DABCO and HFBA under air at room temperature. Aryl ketones could be easily synthesized via the hydrolysis of the ketimine moiety generated in situ without the need for additional water.

Graphical abstract: Acid-promoted denitrogenative Pd-catalyzed addition of arylhydrazines with nitriles at room temperature

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Article information

DOI
https://doi.org/10.1039/C6QO00634E
Article type
Research Article
Submitted
15 Oct 2016
Accepted
09 Dec 2016
First published
13 Dec 2016

Org. Chem. Front., 2017,4, 398-403

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Acid-promoted denitrogenative Pd-catalyzed addition of arylhydrazines with nitriles at room temperature

K. Cheng, G. Wang, M. Meng and C. Qi, Org. Chem. Front., 2017, 4, 398 DOI: 10.1039/C6QO00634E

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