Cp2TiCl2-catalyzed hydrocarboxylation of alkynes with CO2: formation of α,β-unsaturated carboxylic acids

Peng Shao; Sheng Wang; Gaixia Du; Chanjuan Xi

doi:10.1039/C6RA25003C

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Cp₂TiCl₂-catalyzed hydrocarboxylation of alkynes with CO₂: formation of α,β-unsaturated carboxylic acids†

Peng Shao,^a Sheng Wang,^a Gaixia Du*^a and Chanjuan Xi*^ab

Author affiliations

* Corresponding authors

^a Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China

^b State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
E-mail: cjxi@tsinghua.edu.cn

Abstract

Cp₂TiCl₂-catalyzed hydrocarboxylation of alkynes with CO₂ (atmospheric pressure) has been reported. A range of alkynes were transformed to the corresponding α,β-unsaturated carboxylic acids in high yields with high regioselectivity. The reaction proceeded with hydrotitanation, transmetalation, and subsequently carboxylation with CO₂.

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Article information

DOI: https://doi.org/10.1039/C6RA25003C
Article type: Paper
Submitted: 10 Oct 2016
Accepted: 22 Nov 2016
First published: 13 Jan 2017
This article is Open Access

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RSC Adv., 2017,7, 3534-3539

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Cp₂TiCl₂-catalyzed hydrocarboxylation of alkynes with CO₂: formation of α,β-unsaturated carboxylic acids

P. Shao, S. Wang, G. Du and C. Xi, RSC Adv., 2017, 7, 3534 DOI: 10.1039/C6RA25003C

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