Issue 16, 2017

Furan-carboxamide derivatives as novel inhibitors of lethal H5N1 influenza A viruses

Abstract

In this study, we reported the synthesis and biological characterization of a novel series of furan-carboxamide derivatives that were potent inhibitors of the influenza A H5N1 virus. The systematic structure–activity relationship (SAR) studies demonstrated that the 2,5-dimethyl-substituted heterocyclic moiety (furan or thiophene) had significant influence on the anti-influenza activity. In particular, 2,5-dimethyl-N-(2-((4-nitrobenzyl)thio)ethyl)-furan-3-carboxamide 1a showed the best activity against the H5N1 virus with an EC50 value of 1.25 μM. For the first time, the simple scaffold furan-carboxamide derivatives were identified as novel inhibitors of lethal H5N1 influenza A virus.

Graphical abstract: Furan-carboxamide derivatives as novel inhibitors of lethal H5N1 influenza A viruses

Supplementary files

Article information

Article type
Paper
Submitted
09 Jan 2017
Accepted
23 Jan 2017
First published
01 Feb 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 9620-9627

Furan-carboxamide derivatives as novel inhibitors of lethal H5N1 influenza A viruses

Y. Yu, J. Zheng, L. Cao, S. Li, X. Li, H. Zhou, X. Liu, S. Wu and C. Dong, RSC Adv., 2017, 7, 9620 DOI: 10.1039/C7RA00305F

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