Issue 26, 2017, Issue in Progress
From the journal:

RSC Advances

Discovery of 1,3-diyne compounds as novel and potent antidepressant agents: synthesis, cell-based assay and behavioral studies†

Kai-Qing Ma, ORCID logo *a   Yan-Hong Miao,ab   Xiao Li,ab   Yu-Zhi Zhou, ORCID logo a   Xiao-Xia Gao,a   Xiang Zhang,d   Jian-Bin Chaoc  and  Xue-Mei Qin*a  

* Corresponding authors

a Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, P. R. China
E-mail: makaiqing@sxu.edu.cn

b College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, P. R. China

c Scientific Instrument Center, Shanxi University, Taiyuan 030006, P. R. China

d Department of Chemistry, University of Louisville, Louisville, KY 40208, USA

Abstract

Sixteen 1,3-diynes compounds were designed and synthesized. Their protective effects on corticosterone-injured PC12 cells were evaluated. Among them, five compounds (7a, 7c, 7d, 11, 12) displayed significant protective activity at 10 μmol. Moreover, the protective activity of compound 7a was proved to be associated with the regulation of the apoptosis related proteins. The mice forced swim test showed that 7a had a concentration-dependent antidepressant-like effect. Overall, our findings support that compound 7a is a promising lead candidate that deserves further evaluation in the design of antidepressants.

Graphical abstract: Discovery of 1,3-diyne compounds as novel and potent antidepressant agents: synthesis, cell-based assay and behavioral studies

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C7RA01268C
Article type
Paper
Submitted
30 Jan 2017
Accepted
06 Mar 2017
First published
13 Mar 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 16005-16014

Permissions

Request permissions

Discovery of 1,3-diyne compounds as novel and potent antidepressant agents: synthesis, cell-based assay and behavioral studies

K. Ma, Y. Miao, X. Li, Y. Zhou, X. Gao, X. Zhang, J. Chao and X. Qin, RSC Adv., 2017, 7, 16005 DOI: 10.1039/C7RA01268C

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements