Issue 71, 2017, Issue in Progress
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RSC Advances

Specific identification of human transferrin conformations using a cyanine dye supramolecular assembly†

Xiufeng Zhang, ORCID logo *a   Ling Lan,ab   Shu Yang,c   Yulan Rui,a   Qian Li,d   Hongbo Chen,bd   Xin Sun,a   Qianfan Yang ORCID logo *e  and  Yalin Tang ORCID logo *d  

* Corresponding authors

a College of Chemical Engineering, North China University of Science and Technology, Tangshan, P. R. China
E-mail: xfzhang@iccas.ac.cn, zhangxf@ncst.edu.cn
Tel: +86-315-8805460

b Graduate University of Chinese Academy of Sciences, Beijing 100080, P. R. China

c West China School of Pharmacy, Sichuan University, Chengdu, P. R. China

d Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry Chinese Academy of Sciences, Beijing, P. R. China
E-mail: tangyl@iccas.ac.cn

e College of Chemistry, Sichuan University, Chengdu, P. R. China
E-mail: yangqf@scu.edu.cn

Abstract

A new method to recognize human transferrin (Tf) conformations was developed using a cyanine dye supramolecular assembly. We achieved detection of the open conformation of Tf (apo-Tf) in a sub-micromolar level against the closed one (holo-Tf). As a protein conformational probe, it's promising to monitor the transition between the two conformations of Tf.

Graphical abstract: Specific identification of human transferrin conformations using a cyanine dye supramolecular assembly

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Article information

DOI
https://doi.org/10.1039/C7RA04272H
Article type
Paper
Submitted
15 Apr 2017
Accepted
12 Sep 2017
First published
20 Sep 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 44904-44907

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Specific identification of human transferrin conformations using a cyanine dye supramolecular assembly

X. Zhang, L. Lan, S. Yang, Y. Rui, Q. Li, H. Chen, X. Sun, Q. Yang and Y. Tang, RSC Adv., 2017, 7, 44904 DOI: 10.1039/C7RA04272H

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