Issue 47, 2017, Issue in Progress

Self-assembled nanoparticles based on poly(ethylene glycol)–oleanolic acid conjugates for co-delivery of anticancer drugs

Abstract

Oleanolic acid (OA) has shown promising antitumor activity. However, it is difficult to formulate because of its poor water solubility and low bioavailability. In this study, self-assembled nanoparticles based on poly(ethylene glycol)–oleanolic acid conjugates (mPEG–OA) for co-delivery of anticancer drugs were developed to enhance the properties of OA. The mPEG–OA was synthesized by conjugating oleanolic acid (OA) to methoxy poly(ethylene glycol) carboxylic acid (mPEG–COOH). Then hydroxycamptothecin (HCPT), another anticancer drug was encapsulated into the mPEG–OA conjugates by the nanoprecipitation method. The mPEG–OA/HCPT nanoparticles (NPs) had an appropriate size, high drug loading of OA and HCPT, high stability, slow drug release and low cytotoxicity. In vivo studies revealed that the nanoparticles significantly improved the antitumor activity compared with free drugs. As no systemic toxicity was observed, the mPEG–OA NPs can serve as a promising drug delivery system for cancer therapy.

Graphical abstract: Self-assembled nanoparticles based on poly(ethylene glycol)–oleanolic acid conjugates for co-delivery of anticancer drugs

Article information

Article type
Paper
Submitted
18 Apr 2017
Accepted
25 May 2017
First published
07 Jun 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 29591-29598

Self-assembled nanoparticles based on poly(ethylene glycol)–oleanolic acid conjugates for co-delivery of anticancer drugs

Y. Wang, Y. Tian, P. Zhu, Y. Ma, J. He and J. Lei, RSC Adv., 2017, 7, 29591 DOI: 10.1039/C7RA04366J

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