Synthesis, characterization, and evaluation of PEGylated first-row transition metal ferrite nanoparticles as T2 contrast agents for high-field MRI

Abhinandan Banerjee; Barbara Blasiak; Eva Pasquier; Boguslaw Tomanek; Simon Trudel

doi:10.1039/C7RA05495E

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Synthesis, characterization, and evaluation of PEGylated first-row transition metal ferrite nanoparticles as T₂ contrast agents for high-field MRI†

Abhinandan Banerjee,

^a Barbara Blasiak,^bc Eva Pasquier,^ad Boguslaw Tomanek^bce and Simon Trudel

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, Institute for Quantum Science and Technology, University of Calgary, 2500 University Dr NW, Calgary, AB, Canada
E-mail: trudels@ucalgary.ca

^b Department of Clinical Neurosciences, University of Calgary, 3330 Hospital Dr NW, Calgary, AB T2N 4N1, Canada

^c Institute of Nuclear Physics, Polish Academy of Sciences, 152 Radzikowskiego, Krakow, Poland

^d École Européenne de Chimie, Polymères et Matériaux de Strasbourg (ECPM), 25 Rue Becquerel, 67087 Strasbourg, France

^e Oncology Department, University of Alberta, 8303-112 St., Edmonton, AB T6G 2T4, Canada

Abstract

Poly(ethylene glycol) (PEG)-coated transition metal ferrite (MFe₂O₄; M = Co, Cu, Fe, Mn, Ni, Zn) nanoparticles (NPs) were generated by a one-pot synthetic protocol and found to be small, fairly monodisperse, and superparamagnetic in nature. When evaluated for high-field magnetic resonance imaging, these showed high values of r₂ and r₂/r₁ at 9.4 T. The well-documented biocompatibility of PEG coatings makes these NPs attractive candidates as T₂ contrast agents for high-field MRI. A systematic comparison of magnetic and relaxivity measurements reveals MnFe₂O₄ and CoFe₂O₄ NPs to be superior T₂ MRI contrast agents compared to Fe₃O₄ NPs.

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Article information

DOI: https://doi.org/10.1039/C7RA05495E
Article type: Paper
Submitted: 15 May 2017
Accepted: 15 Jul 2017
First published: 02 Aug 2017
This article is Open Access

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RSC Adv., 2017,7, 38125-38134

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Synthesis, characterization, and evaluation of PEGylated first-row transition metal ferrite nanoparticles as T₂ contrast agents for high-field MRI

A. Banerjee, B. Blasiak, E. Pasquier, B. Tomanek and S. Trudel, RSC Adv., 2017, 7, 38125 DOI: 10.1039/C7RA05495E

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