Multi-functional thermo-crosslinkable collagen-metal nanoparticle composites for tissue regeneration: nanosilver vs. nanogold

K. Hosoyama; M. Ahumada; C. D. McTiernan; J. Bejjani; F. Variola; M. Ruel; B. Xu; W. Liang; E. J. Suuronen; E. I. Alarcon

doi:10.1039/C7RA08960K

Multi-functional thermo-crosslinkable collagen-metal nanoparticle composites for tissue regeneration: nanosilver vs. nanogold†

K. Hosoyama,‡^a M. Ahumada,

‡^a C. D. McTiernan,^a J. Bejjani,^a F. Variola,^b M. Ruel,^ac B. Xu,^cd W. Liang,^cd E. J. Suuronen*^ac and E. I. Alarcon

*^ae

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* Corresponding authors

^a Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, Canada
E-mail: Esuuronen@ottawaheart.ca, Ealarcon@ottawaheart.ca

^b Department of Mechanical Engineering, University of Ottawa, Ontario, Canada

^c Department of Cellular and Molecular Medicine, University of Ottawa, Canada

^d Cardiac Electrophysiology Lab, University of Ottawa Heart Institute, Canada

^e Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Canada

Abstract

Collagen–silver/gold biomimetic matrices were developed for cardiac tissue engineering. The incorporation of nanoparticles led to modifications in the 3D structure of the collagen matrices, with gold increasing the materials' viscosity by ≈4 times. Electrical conductivity was also enhanced upon addition of the nanoparticles. The materials promoted reparative macrophage migration and improved the proliferation and function of neonatal cardiomyocytes under electrical stimulation.

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Multi-functional thermo-crosslinkable collagen-metal nanoparticle composites for tissue regeneration: nanosilver vs. nanogold†

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Multi-functional thermo-crosslinkable collagen-metal nanoparticle composites for tissue regeneration: nanosilver vs. nanogold

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