Issue 83, 2017, Issue in Progress
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RSC Advances

A near-infrared phosphorescent iridium(iii) complex for imaging of cysteine and homocysteine in living cells and in vivo†

Yongquan Wu, ORCID logo a   Renmiao Wu,a   Huifang Li,a   Hong Zeng,a   Yuanyan Li,a   Qiuhong Wang,b   Mei Shi*b  and  Xiaolin Fan*a  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Key Laboratory of Organo-pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou, P. R. China
E-mail: fanxl2013@gnnu.cn

b Department of Chemistry, Fudan University, Shanghai 200433, P. R. China
E-mail: shimei@fudan.edu.cn

Abstract

Based on the cyclization reaction of an aldehyde with an aminoalkyl thiol, a novel NIR-emitting iridium(III) complex (NIR-Ir) showed off–on phosphorescent response toward Cys and Hcy, and was developed to detect Cys/Hcy levels in vitro and in vivo.

Graphical abstract: A near-infrared phosphorescent iridium(iii) complex for imaging of cysteine and homocysteine in living cells and in vivo

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Article information

DOI
https://doi.org/10.1039/C7RA09798K
Article type
Paper
Submitted
03 Sep 2017
Accepted
06 Nov 2017
First published
14 Nov 2017
This article is Open Access
Creative Commons BY license

RSC Adv., 2017,7, 52621-52625

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A near-infrared phosphorescent iridium(III) complex for imaging of cysteine and homocysteine in living cells and in vivo

Y. Wu, R. Wu, H. Li, H. Zeng, Y. Li, Q. Wang, M. Shi and X. Fan, RSC Adv., 2017, 7, 52621 DOI: 10.1039/C7RA09798K

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