Issue 86, 2017

Targeting protein-loaded CB[8]-mediated supramolecular nanocarriers to cells

Abstract

Supramolecular amphiphiles, consisting of ternary complexes of cucurbit[8]uril (CB[8]), an alkylated paraquat derivative and a tetraethylene glycol-functionalized azobenzene, self-assemble into vesicles of about 200 nm in diameter. The outer surface of the vesicles was functionalized with cell-targeting ligands. These vesicles were employed for loading and delivery of proteins into cells. Supramolecular amphiphile-derived vesicles show great promise as nanocarriers of functional molecules to be transferred into cells.

Graphical abstract: Targeting protein-loaded CB[8]-mediated supramolecular nanocarriers to cells

Supplementary files

Article information

Article type
Paper
Submitted
05 Oct 2017
Accepted
21 Nov 2017
First published
27 Nov 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 54341-54346

Targeting protein-loaded CB[8]-mediated supramolecular nanocarriers to cells

E. Cavatorta, J. Voskuhl, D. Wasserberg, J. Brinkmann, J. Huskens and P. Jonkheijm, RSC Adv., 2017, 7, 54341 DOI: 10.1039/C7RA10980F

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