Issue 3, 2017

Continuous flow telescopic oxidation of alcohols via generation of chlorine and hypochlorite

Abstract

A 3-step continuous flow oxidation of alcohols is demonstrated with continuous generation of chlorine as the first step followed by its use for the flow synthesis of high strength sodium hypochlorite. The solution is subsequently used for oxidation of alcohols in the presence of a catalytic amount of the nitroxyl radical “TEMPO”, which inhibits oxidation at the aldehyde stage. Selective oxidations of eight different alcohols were demonstrated. To achieve identical yields, the aromatic alcohols containing electron withdrawing groups needed a longer residence time than aliphatic alcohols.

Graphical abstract: Continuous flow telescopic oxidation of alcohols via generation of chlorine and hypochlorite

Supplementary files

Article information

Article type
Communication
Submitted
19 Dec 2016
Accepted
15 Mar 2017
First published
15 Mar 2017

React. Chem. Eng., 2017,2, 304-308

Continuous flow telescopic oxidation of alcohols via generation of chlorine and hypochlorite

Y. Sharma, S. Moolya, R. A. Joshi and A. A. Kulkarni, React. Chem. Eng., 2017, 2, 304 DOI: 10.1039/C6RE00225K

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