Micromixing enables chemoselective reactions of difunctional electrophiles with functional aryllithiums

Aiichiro Nagaki; Satoshi Ishiuchi; Keita Imai; Kengo Sasatsuki; Yuichi Nakahara; Jun-ichi Yoshida

doi:10.1039/C7RE00142H

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Micromixing enables chemoselective reactions of difunctional electrophiles with functional aryllithiums†

Aiichiro Nagaki,

*^a Satoshi Ishiuchi,^a Keita Imai,^a Kengo Sasatsuki,^a Yuichi Nakahara^b and Jun-ichi Yoshida*^a

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* Corresponding authors

^a Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan
E-mail: yoshida@sbchem.kyoto-u.ac.jp, anagaki@sbchem.kyoto-u.ac.jp

^b Process Engineering Group, Fundamental Technology Labs. Institute of Innovation, Ajinomoto Co., Inc., 1-1 Suzuki-cho, Kawasaki-ku, Kanagawa 210-8681, Japan

Abstract

Generation of highly unstable functional aryllithiums followed by chemoselective reactions with difunctional electrophiles were successfully achieved using flow microreactor systems equipped with micromixers to give highly functionalized compounds without protecting functional groups. Extremely fast micromixing is responsible for high chemoselectivity.

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Article information

DOI: https://doi.org/10.1039/C7RE00142H
Article type: Paper
Submitted: 07 Sep 2017
Accepted: 06 Oct 2017
First published: 16 Oct 2017

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React. Chem. Eng., 2017,2, 862-870

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Micromixing enables chemoselective reactions of difunctional electrophiles with functional aryllithiums

A. Nagaki, S. Ishiuchi, K. Imai, K. Sasatsuki, Y. Nakahara and J. Yoshida, React. Chem. Eng., 2017, 2, 862 DOI: 10.1039/C7RE00142H

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Reaction Chemistry & Engineering

Micromixing enables chemoselective reactions of difunctional electrophiles with functional aryllithiums†

Abstract

Supplementary files

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Micromixing enables chemoselective reactions of difunctional electrophiles with functional aryllithiums

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