Issue 3, 2017

Light responsive metal–organic frameworks as controllable CO-releasing cell culture substrates

Abstract

A new carbon monoxide (CO)-releasing material has been developed by embedding a manganese carbonyl complex, MnBr(bpydc)(CO)3 (bpydc = 5,5′-dicarboxylate-2,2′-bipyridine) into a highly robust Zr(IV)-based metal–organic framework (MOF). Efficient and controllable CO-release was achieved under exposure to low intensity visible light. Size-controllable nanocrystals of the photoactive MOF were obtained and their CO-releasing properties were correlated with their crystal sizes. The photoactive crystals were processed into cellular substrates with a biocompatible polymer matrix, and the light-induced delivery of CO and its subsequent cellular uptake were monitored using a fluorescent CO-probe. The results discussed here demonstrate a new opportunity to use MOFs as macromolecular scaffolds towards CO-releasing materials and the advantage of MOFs for high CO payloads, which is essential in future therapeutic applications.

Graphical abstract: Light responsive metal–organic frameworks as controllable CO-releasing cell culture substrates

Supplementary files

Article information

Article type
Edge Article
Submitted
31 Oct 2016
Accepted
21 Dec 2016
First published
21 Dec 2016
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2017,8, 2381-2386

Light responsive metal–organic frameworks as controllable CO-releasing cell culture substrates

S. Diring, A. Carné-Sánchez, J. Zhang, S. Ikemura, C. Kim, H. Inaba, S. Kitagawa and S. Furukawa, Chem. Sci., 2017, 8, 2381 DOI: 10.1039/C6SC04824B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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