Copper-catalyzed oxidative C(sp3)–H/C(sp2)–H cross-coupling en route to carbocyclic rings

Rui Wang; Yan Li; Ruo-Xing Jin; Xi-Sheng Wang

doi:10.1039/C7SC00250E

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Copper-catalyzed oxidative C(sp³)–H/C(sp²)–H cross-coupling en route to carbocyclic rings†

Rui Wang,

^a Yan Li,

^a Ruo-Xing Jin

^a and Xi-Sheng Wang

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, China
E-mail: xswang77@ustc.edu.cn

Abstract

Copper-catalyzed selective coupling of C(sp³)–H bonds with C(sp²)–H bonds has been developed. An aniline module was used as a directing group to generate an aminyl radical, which selectively cleaves the secondary and tertiary C(sp³)–H bonds via a 1,5-HAT process to forge six-membered carbocyclic rings.

Download options Please wait...

Supplementary files

Supplementary information PDF (12958K)

Article information

DOI: https://doi.org/10.1039/C7SC00250E
Article type: Edge Article
Submitted: 18 Jan 2017
Accepted: 14 Mar 2017
First published: 15 Mar 2017
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry

Download Citation

Chem. Sci., 2017,8, 3838-3842

Permissions

Request permissions

Copper-catalyzed oxidative C(sp³)–H/C(sp²)–H cross-coupling en route to carbocyclic rings

R. Wang, Y. Li, R. Jin and X. Wang, Chem. Sci., 2017, 8, 3838 DOI: 10.1039/C7SC00250E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Science