Enzyme-free quantification of exosomal microRNA by the target-triggered assembly of the polymer DNAzyme nanostructure

Dinggeng He; Luo Hai; Huizhen Wang; Ri Wu; Hung-Wing Li

doi:10.1039/C7AN01691C

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Enzyme-free quantification of exosomal microRNA by the target-triggered assembly of the polymer DNAzyme nanostructure†

Dinggeng He,^ab Luo Hai,^b Huizhen Wang,^b Ri Wu^b and Hung-Wing Li

*^a

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* Corresponding authors

^a Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
E-mail: hwli@hkbu.edu.hk

^b State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China

Abstract

We herein report an efficient hybridization chain reaction (HCR)- and DNAzyme-based enzyme-free signal amplification for the detection of specific exosomal miRNAs in the culture medium of cancer cells and serum samples from cancer patients via the target-triggered self-assembly of the polymer DNAzyme nanostructure.

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Article information

DOI: https://doi.org/10.1039/C7AN01691C
Article type: Communication
Submitted: 06 Nov 2017
Accepted: 06 Jan 2018
First published: 08 Jan 2018

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Analyst, 2018,143, 813-816

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Enzyme-free quantification of exosomal microRNA by the target-triggered assembly of the polymer DNAzyme nanostructure

D. He, L. Hai, H. Wang, R. Wu and H. Li, Analyst, 2018, 143, 813 DOI: 10.1039/C7AN01691C

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Enzyme-free quantification of exosomal microRNA by the target-triggered assembly of the polymer DNAzyme nanostructure†

Abstract

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Enzyme-free quantification of exosomal microRNA by the target-triggered assembly of the polymer DNAzyme nanostructure

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