SPIONs for cell labelling and tracking using MRI: magnetite or maghemite?†
Michael
Barrow, 
‡a
Arthur
Taylor,
‡b
Luke M.
Daniels,
a
Matthew J.
Rosseinsky
*a
and
Dave J.
Adams
*ad
‡a
Arthur
Taylor,
‡b
Luke M.
Daniels,
a
Matthew J.
Rosseinsky
*a
and
Dave J.
Adams
*ad
Abstract
Although there is extensive literature covering the biomedical applications of superparamagnetic iron oxide nanoparticles (SPIONs), the phase of the iron oxide core used is not often taken into account when cell labelling and tracking studies for regenerative medicine are considered. Here, we use a co-precipitation reaction to synthesise particles of both magnetite- (Fe3O4) and maghemite- (γ-Fe2O3) based cores and consider whether the extra synthesis step to make maghemite based particles is advantageous for cell tracking.
- This article is part of the themed collections: In memory of Paul O’Brien and 7th EuCheMS Chemistry Congress – Molecular frontiers and global challenges
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