Mechanistic insight into the singlet oxygen-triggered expansion of hypoxia-responsive polymeric micelles

Lina Wang; Xiaoli Huang; Bingbing Wang; Jie Zhao; Xuliang Guo; Zheng Wang; Yanjun Zhao

doi:10.1039/C8BM00369F

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Mechanistic insight into the singlet oxygen-triggered expansion of hypoxia-responsive polymeric micelles†

Lina Wang,

‡^a Xiaoli Huang,

‡^a Bingbing Wang,

^a Jie Zhao,

^a Xuliang Guo,

^a Zheng Wang

^a and Yanjun Zhao

*^a

Author affiliations

* Corresponding authors

^a School of Pharmaceutical Science & Technology, Tianjin Key Laboratory for Modern Drug Delivery & High Efficiency, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin University, Tianjin 300072, China
E-mail: zhaoyj@tju.edu.cn

Abstract

Nitroimidazole-bearing nanomedicine has been popular as a hypoxia-responsive platform for on-demand drug delivery. We report the singlet oxygen-responsive property of nitroimidazole-containing micelles and the corresponding reaction mechanism, which would pave the way for developing a dual hypoxia- and singlet oxygen-sensitive drug delivery nanoplatform based on a simple nitroimidazole moiety.

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Article information

DOI: https://doi.org/10.1039/C8BM00369F
Article type: Communication
Submitted: 29 Mar 2018
Accepted: 14 May 2018
First published: 15 May 2018

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Biomater. Sci., 2018,6, 1712-1716

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Mechanistic insight into the singlet oxygen-triggered expansion of hypoxia-responsive polymeric micelles

L. Wang, X. Huang, B. Wang, J. Zhao, X. Guo, Z. Wang and Y. Zhao, Biomater. Sci., 2018, 6, 1712 DOI: 10.1039/C8BM00369F

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Biomaterials Science

Mechanistic insight into the singlet oxygen-triggered expansion of hypoxia-responsive polymeric micelles†

Abstract

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Mechanistic insight into the singlet oxygen-triggered expansion of hypoxia-responsive polymeric micelles

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